Unfortunately, vitamin K2 and CoQ10 have very low aqueous solubility and a relatively high molecular weight, rendering them poorly bioavailable after oral administration. To overcome these limitations, SourceOne utilizes the VESIsorb® delivery system which has been clinically proven to dramatically improve the pharmacokinetic parameters (Cmax, Tmax, and AUC).
The peer-reviewed journal, Alternative Therapies in Health & Medicine, published a human pharmacokinetic study comparing the VESIsorb® CoQ10 formulation with three marketed "bio-enhanced" CoQ10 formulas. The data of this study as well as a comparison with available published literature shows an unmatched enhancement of CoQ10 bioavailability achieved by the VESIsorb® CoQ10 formulation.
The benefits are unmatched:
- Faster onset, independent of food/fat status.
- Fewer servings required to achieved the desired therapeutic effect.
- Superior loading for smaller and easier to consumer capsules.
- Addressing issues related to poor absorption like age, diet, and gender.
Simply put, this formula delivers unmatched blood plasma levels of both vitamin K2 and CoQ10 in an elegant softgel capsule.
Although vitamin K has long been thought of as a nutrient related to bone health, emerging science continues to demonstrate its importance in cardiovascular health. Matrix-Gla protein (MGP) is an important protein that helps to regulate the handling of calcium within the body, specifically the deposition of calcium within vessels. As a result, MGP plays a vital role in our vascular health. MGP is also a vitamin K-dependent protein, and a sufficient circulating level of vitamin K is required in order to maintain the optimal function of this protein. If vitamin K levels are insufficient, the protein becomes uncarboxylated and favors the deposition of calcium in the vasculature. Supplementation with vitamin K2 (MK7) in humans at a dose of 180 mcg/day over a three year period has been shown to have a beneficial effect on vascular elasticity.
CoQ10 is well known for its ability to support cardiovascular health. As an essential component of the mitochondrial electron transport chain, CoQ10 is critically important for the production of cellular energy. CoQ10 also acts as an antioxidant, providing important protection from damaging free radicals, in turn helping to protect the endothelium. Numerous human clinical studies have demonstrated that supplementation with CoQ10 can significantly benefit cardiovascular function.